Among these 76 patients, 72 (34.8% of 207 with suspected CRS, all of whom met clinical criteria) were classified as laboratory-confirmed CRS, and four were categorized as having congenital rubella infection (positive rubella IgM in the absence of cataracts, congenital glaucoma, pigmentary retinopathy, congenital heart defects, or hearing loss (Box). Here, CD40LG is linked to congenital rubella syndrome.