SAMD9L and adrenal gland pheochromocytoma: On the contrary, the 2 rare germline variants of SAMD9L detected in two sporadic PCC cases were both producing a premature STOP of the protein (a p.N769fs frameshift deletion and a nonsense p.R406X) and were associated with significant downregulation of SAMD9L mRNA, supporting the pathogenicity of these alterations.