There are multiple EBPs present in the malaria parasite Pk (α, β, and γ), and it is the Pkα-DBL and Pv-DBL that mediate Duffy antigen receptor for chemokines (DARC)-dependent invasion of erythrocytes in humans (Choe et al., 2005; Hans et al., 2005; Chitnis and Sharma, 2008). Here, ACKR1 is linked to malaria.