Malkin et al. (1990) later described a genetic cause of another rare cancer predisposition disease, so-called Li-Fraumeni syndrome: it turned out that this severe multiorgan tumor syndrome is caused by then already well-known suppressor gene p53. Soon afterwards, Nishisho et al. (1991) and Kinzler et al. (1991) discovered the genetic basis of familial adenomatous polyposis (FAP), i.e., germ-line mutations in APC (adenomatous polyposis coli) gene. Here, APC is linked to Li-Fraumeni syndrome.