According to Wu et al. (39), the potential role of GnRH in promoting the cell migration and invasion of endometrial cancer is through the binding of GnRH-I receptors, the activation of the ERK1/2 and JNK pathways, and the subsequent induction of the metastasis-related matrix metalloproteinase-2 activity. This evidence concerns the gene MAPK3 and endometrial cancer.