Finally, the contribution of CD44/CD44v6 to metastatic settlement being promoted by tumor exosomes (TEX), which are suggested to transfer CIC-features to Non-CIC, to promote angiogenesis, to prepare a premetastatic niche and to modulate hematopoiesis toward an immunosuppressive phenotype (Hannafon and Ding, 2015; Minciacchi et al., 2015), will be discussed. Here, CD44 is linked to neoplasm.