To give a few, selected examples: In gastric-CIC, flow-stimulated invasion was reduced by a blockade of CXCR4, SDF1, and/or CD44 (Kingsmore et al., 2016); in HNSCC, formation of podia and cell migration essentially depend on CD44 and CXCR4 expression (Faber et al., 2013). This evidence concerns the gene CXCR4 and head and neck squamous cell carcinoma.