Information so far implies CIC-TEX to transfer CIC-features into Non-CIC, to modulate the tumor stroma, to promote angiogenesis, to account for the formation of a premetastatic niche and to redirect hematopoietic progenitor maturation toward an immunosuppressive phenotype (Azmi et al., 2013; Kosaka et al., 2014; Whiteside, 2016; Sato and Weaver, 2018; Sundararajan et al., 2018; Zhang et al., 2018). This evidence concerns the gene TEX46 and neoplasm.