A significant reduction or lack of expression of WWOX gene was observed mainly in breast cancer, but also (amongst other) in esophageal squamous cell carcinomas (12), non-small lung cancers (14, 21), pancreatic tumors (15, 16, 22) prostate, (23), gastric, ovarian (24), thyroid (18, 25), and bladder (26) cancers. The gene discussed is WWOX; the disease is breast carcinoma.