The level of WWOX expression correlated with ER and PR status in a quantitative real-time RT-PCR study of 132 breast cancer cases: significantly higher WWOX expression was observed in ER+ tumors compared to ER– tumors, as well as in PR positive cancers compared to PR negatives, and in ER+PR+ tumors compared to ER–PR– cases (88). Here, ESR1 is linked to cancer.