It can target the Ran GTPase Activating Protein 1 (RanGAP1) mRNA, as demonstrated by inverse correlation in CML patients: the RanGAP1 protein down-regulation or an increased miR-1301 are beneficial for the sensitivity to imatinib (452). Here, RANGAP1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.