SLC16A3 and oral cavity squamous cell carcinoma: In this study we investigated the role of MCT4 in the progression of OSCC in a well-established model of oral squamous cell carcinoma using the carcinogen 4-nitroquinoline-1-oxide (4NQO) (18) in wild type (MCT4+/+) and MCT4 knockout (MCT4−/−) mice.