We hypothesized that blockade of VEGF using the clinically available anti-angiogenic therapy, VEGF-Trap (Eylea/Aflibercept), we would improve dendritic cell maturation and in turn improve antitumor T cell responses in a murine model of GBM, the GL261-quad cassette syngeneic glioma. This evidence concerns the gene VEGFA and glioblastoma.