Our group has previously demonstrated that treatment with VEGF-Trap, which is a VEGF receptor (VEGFR) fusion protein conjugated to a human IgG Fc region, results in similar outcomes as GBM patients treated with bevacizumab anti-angiogenic therapies as measured by T1- and T2-weighted magnetic resonance imaging (MRI) and histology (5). The gene discussed is VEGFA; the disease is glioblastoma.