CD274 and neoplasm: KEYNOTE-040 described an OS HR of 0.54 (95% CI 0.35–0.82) with pembrolizumab in patients with tumors with PD-L1 expression >50% but also evaluated PD-L1 expression on both tumor and associated immune cells (CPS score) describing OS HR of 0.75 for PD-L1 CPS >1% with pembrolizumab compared to control patients.