Mast cells are the “first line of defense” in which innate/adaptive immune cells can be activated to release a wide range of mediators by allergen-IgE-specific triggers and are widely distributed in tissues of the airway exposed to the environment, so mast cells preempt the critical roles played by histamine and mucus secretion in causing airway obstruction [31, 32]. Here, IGHE is linked to Airway obstruction.