For example, epigenetic changes through the hyper-methylation of the BMAL1 promoter has been associated with the development of hematological malignancies such as non-Hodgkin lymphoma and acute lymphocytic leukemia (ALL), and hyper-methylation of the Per3 gene is manifested in chronic myeloid leukemia (CML) in peripheral blood [9]. The gene discussed is PER3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.