Although in our study we did also see significant down-regulation of BMAL1 and Per2 in patients newly diagnosed with CLL (Figure 3C), we also saw significant down-regulation in the core clock gene, Cry2 as well as the ancillary clock gene Rev-ERBa (Figure 3C and Figure 3D). Here, NR1D1 is linked to B-cell chronic lymphocytic leukemia.