Although we did also observe disrupted oscillations in Per2 and Cry2 in patients newly diagnosed with CML, the lack of oscillation was not just restricted to these circadian genes but also included additional core clock genes such as BMAL1 and CLOCK, as well as ancillary clock genes such as Rev-ERBa and PPARa (Figure 4). Here, CLOCK is linked to chronic myelogenous leukemia, BCR-ABL1 positive.