In this context, it has been demonstrated that, in fibroblasts, GM1 is able to inhibit the ligand-mediated phosphorylation of tyrosine residues of the cytoplasmic tail of the receptor [27], as well as the ligand-induced intracellular association of SH2-containing proteins with PDGFR in human glioma cells [28]. The gene discussed is PDGFRB; the disease is central nervous system cancer.