ALOX5 and multiminicore myopathy: However, although the importance of 5-LO in monocytes during MMD with subsequent vascular inflammation was identified, the 5-LO-linked signaling in monocytes mediating MMD need to be identified to develop specific target-based therapeutics, because 5-LO in monocytes exert its action via production of various leukotrienes (LT) including LTB4 and cysteinyl LTs.