ITGAM and multiminicore myopathy: As shown in Figure 3, HMGB1-induced expression of CD11b/Mac-1 on BMDCs was markedly attenuated in BLTR1-depleted cells using siRNA as well as in BLTR1-deficient cells isolated from BLTR1-deficient mice, suggesting a pivotal involvement of BLTR1 in HMGB1-induced MMD.