Immunocytochemistry of HMGB1-stimulated BMDCs also revealed that the surface expression of CD11b/Mac-1 (red) was markedly increased, which was significantly attenuated by pre-treatment with Zileuton, suggesting a potential role for 5-LO in MMD induced by HMGB1 (Figure 1C). The gene discussed is ITGAM; the disease is multiminicore myopathy.