HMGB1 and multiminicore myopathy: Although LTB4 (1–10 ng/ml) had minimal direct effects on MMD in control and 5-LO-deficient BMDCs (Supplementary Figure 3), the attenuated MMD in 5-LO-deficient cells stimulated with HMGB1 was significantly reversed to the control level when cells were pre-treated with LTB4 at 10 ng/ml, a concentration comparable to that produced in HMGB1 (100 ng/ml)-stimulated control cells (Figure 4), which indicated the importance of the role played by LTB4 in HMGB1-induced MMD.