The anorexia induced by peripheral Ucn1 is mediated via the CRF2 receptor based on the observation that the selective CRF2 antagonists, antisauvagine-30 and astressin2-B, unlike selective CRF1 antagonists, suppress the Ucn1-induced reduction of food intake (110, 112, 115). The gene discussed is UCN; the disease is Anorexia.