ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Plasma adiponectin showed a minor increase in association with HFD induced obesity (chow ad libitum vs. HFD ad libitum; Figure 3C), which is at variance to most, but not all reports from the literature [e.g. (33–36)], and which was reversed with amelioration of obesity by hypoxia or restricted feeding (Figure 3C).