Even though our study did not directly measure these complex mechanisms, the enhanced reduction in overall systemic hyperglycaemia, in which the frequent metabolic demands within the skeletal muscles possibly enhanced glucose transporter 4 (GLUT4) expression, potentially deceased the diffusion of glucose via GLUT1 into the microvascular complication prone cells, thereby resulting in the favorable effects in HRV and the 10 g monofilament test. Here, SLC2A1 is linked to Hyperglycemia.