The concentration of NfL was higher in the ALS group than in the control group (ASL: median, 2,823 pg/mL, IQR, 1,933–4,658 pg/mL; control: median, 845 pg/mL, IQR, 455–2,552 pg/mL; p < 0.001; Figure 2). The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.