The analyzes realized with the oral mucosa of the animals with OM induced for 5-FU (n = 4), demonstrated intense marking for proteins MMP-9 (Figure 4G; score of 4, p < 0.05), COX-2 (Figure 4H; score of 4, p < 0.05), TGF-β (Figure 4I; score of 4, p < 0.05), and Smad 2/3 (Figure 5, score of 4, p < 0.05), compared with samples of the saline group (Figures 4A–F). The gene discussed is PTGS2; the disease is ocular melanoma.