TELM prevents the 5-FU-induced OM lesions by reducing the expression of the proinflammatory mediators TNF-α, IL-1β, TGF-β, Smad 2/3, COX2, MMP9, and iNOS, by inhibiting NFκB, by increasing the PPARγ gene expression, and by reducing the STAT1 gene expression. Here, NOS2 is linked to ocular melanoma.