TELM prevents the 5-FU-induced OM lesions by reducing the expression of the proinflammatory mediators TNF-α, IL-1β, TGF-β, Smad 2/3, COX2, MMP9, and iNOS, by inhibiting NFκB, by increasing the PPARγ gene expression, and by reducing the STAT1 gene expression. This evidence concerns the gene TGFB1 and ocular melanoma.