Results in this study illustrated that the decreased abundance of p-PI3K, p-Akt, and GLUT4 in T2DM rats were highly up-regulated by SXT, which might indicate that SXT could promote the uptake and utilization of glucose by activating the PI-3K/Akt/GLTU4 pathway and subsequently reduce the blood glucose level in T2DM rats. Here, SLC2A4 is linked to type 2 diabetes mellitus.