AKT1 and type 2 diabetes mellitus: To understand the SXT intervention mechanism of glucose uptake in T2DM rats and make clear whether it was associated with PI-3K-mediated pathway, we detected the mRNA levels of GLUT4, PI-3K, Akt, and protein levels of GLUT4, PI-3K, p-PI-3K, Akt, and p-Akt.