EGFR and cancer: They are based on (1) a well-known overexpression of EGFR (Yewale et al., 2013; Haddad et al., 2017; Xu et al., 2017) and somatostatin receptors (Anthony et al., 2002; Lobachevsky et al., 2012) characteristic of several cancer types, permitting targeting at these surface receptors, and (2) ability of EGFR (Han and Lo, 2012; Bazzani et al., 2018) and somatostatin receptors (Hornick et al., 2000; Wang et al., 2003) to translocate into the cell nucleus together with their ligands/cargos.