Additionally, in the experimental autoimmune encephalomyelitis in animal models the administration of cornel iridoid glycoside significantly attenuated the symptoms of multiple sclerosis via an increased expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) as well as inhibition of JAK/STAT1 and JAK/STAT3 phosphorylation and reduction of proinflammatory mediators, such as TNF-α, IL-1β, IFN-γ, IL-17 (Yin et al., 2014; Qu et al., 2016). This evidence concerns the gene BDNF and multiple sclerosis.