Interestingly, treatment with a caspase-1 inhibitor (Ac-YVAD-CMK) inhibited the motor deficits and improved neuronal survival to both the OHDA- and LPS-induced PD pathology indicating that inflammasome activation and its downstream pathways are critical determinates for PD pathologies (Mao et al., 2017). The gene discussed is CASP1; the disease is Parkinson disease.