IDE and Alzheimer disease: Genetic risk loci associated with late-onset AD include the less-favorable allele of apolipoprotein E (APOE), APOEε4 (Michaelson, 2014), which compromises the ability of APOE to promote clearance of Aβ in conjunction with the insulin degrading enzyme (IDE), therefore encouraging Aβ aggregation in the extracellular region (Kim et al., 2009).