Other coding variants that increase susceptibility for AD include, but are not limited to Karch et al. (2014), proteins involved in innate immune responses such as the triggering receptor expressed on myeloid cells 2 (TREM2), PLCG2 and ABI3 (Sims et al., 2017) and variants of ABCA7 (Steinberg et al., 2015). This evidence concerns the gene TREM2 and Alzheimer disease.