In addition, these dealt only with specific aspects, such as anxiety-related behavior (Leone et al., 2005), depression-related behavior (Agudelo et al., 2014), and certain hippocampal functions (Lucas et al., 2014a; Bartley et al., 2015), and the analyses were performed in different PGC-1α knockout strains, evaluating either only males or females and males in a pooled manner (Table 4). The gene discussed is PPARGC1A; the disease is major depressive disorder.