Among the pioneering publications with PGC-1α-deficient mice, Leone et al. (2005) reported the observation that their whole-body PGC-1α knockout strain (today known as FL-PGC-1α-deficient mice) demonstrated increased avoidance of the central zone in the OF (a.k.a. thigmotaxis), a behavioral alteration interpreted as increased anxiety. The gene discussed is PPARGC1A; the disease is Anxiety.