PPARGC1A and bipolar disorder: Despite the fact that PGC-1α-deficiency has been linked to various neurodegenerative disorders that are associated with psychic alterations (Rona-Voros and Weydt, 2010; Szalardy et al., 2015) and also with schizophrenia (Jiang et al., 2013; McMeekin et al., 2016) and the fact that a GWAS study has linked the chromosomal localization of the PGC-1α gene (PPARGC1A, 4p15.1-2) to schizophrenia and bipolar disorder (Christoforou et al., 2007), only a few studies have addressed psychic behavioral alterations in the literature.