Intriguingly, the pooled analysis of the EPM paradigm not only failed to detect anxiety in FL-PGC-1α -/- compared to wild-type mice, but demonstrated significantly less anxiety-related behavior in this genotype compared to wild-type (closed/total time %: p < 0.001, 52.7% [33.4–67.6%] vs. 70.5% [59.5–77.8%]; Figure 1B). Here, PPARGC1A is linked to Anxiety.