VEGFA and ischemic stroke: Vascular endothelial growth factor (VEGF) is responsible for several processes upon ischemic stroke, including disruption of endothelial cell junctions and endothelial cell endocytosis, followed by increased BBB permeability, and consequently intracranial hemorrhage and intracranial hypertension (Angelo and Kurzrock, 2007; Lange et al., 2016; Suzuki et al., 2016).