These findings are consistent with reports of KCC2 downregulation and changes in the polarity of GABAergic response in animal models of epilepsy (Huberfeld et al., 2007; Barmashenko et al., 2011; Shimizu-Okabe et al., 2011; Kourdougli et al., 2017; Riffault et al., 2018). This evidence concerns the gene SLC12A5 and epilepsy.