MAPT and Alzheimer disease: Based on the increasing risk associated with immunity genes (including TREM2 and CD33) and early neuropathological detection of inflammation in late-onset AD (LOAD), emerging theories also suggest that chronic, aging-associated, inflammation may be an initiating factor leading to the disease-defining neuronal loss, amyloid and tau pathologies of Alzheimer’s (as reviewed in Nazem et al., 2015).