TLR4 and dementia: Moreover, small molecule antagonists of TLR4 have recently been developed (De Paola et al., 2016) and protect against neuro-toxicity using in vitro models of ALS (De Paola et al., 2016) and LPS-induced neuro-inflammation (Perrin-Cocon et al., 2017), suggesting that an investigation of the potential of these drugs in dementia models is warranted.