GSK-3 also plays a well-described role in the generation of AD-associated amyloid β (Aβ) and tau pathologies (Kremer et al., 2011), by promoting abnormal tau phosphorylation (Lucas et al., 2001) and increasing amyloid production (Phiel et al., 2003) and toxicity (DaRocha-Souto et al., 2012). The gene discussed is MAPT; the disease is Alzheimer disease.