Consistent with this association, Golzio et al. (2012) found that morpholino-induced kctd13 knockdown and overexpression of human KCTD13 led to reciprocal phenotypes of macrocephaly and microcephaly, respectively, as well as related changes in cell proliferation in the brains of zebrafish larvae, implicating this gene as a potential driver of head size phenotypes (Golzio et al., 2012). The gene discussed is KCTD13; the disease is microcephaly.