CNTN4 and microcephaly: By altering the expression of three implicated genes in zebrafish in the same direction as the RNA sequencing result from human brain tissue, this study found that morpholino-induced knockdown of the downregulated gene, furina, led to microcephaly and decreased cell proliferation, which was rescued by introducing human FURIN mRNA, while overexpression of the upregulated genes, tsnare and cntn4, led to microcephaly and increased cell proliferation (Fromer et al., 2016).