DISC1 and bipolar disorder: In a subsequent study, Singh et al. (2011) showed that two common variants in DISC1 identified in individuals with schizophrenia and bipolar disorder that lacked Wnt signaling activity in an in vitro assay were unable to rescue structural brain phenotypes in disc1 morphants, further implicating Wnt signaling as an important pathway downstream of DISC1. Another study found evidence for altered hypothalamic development as well as stress responses in zebrafish disc1 mutants (Eachus et al., 2017).