PFN1 and amyotrophic lateral sclerosis: Interestingly, 12 genes (PFN1, TUBA4A, PARK7, SQSTM1, DCTN1, C9orf72, TMEM106B, ALS2, TRPM7, MATR3, SPG11, and ATXN2) have been previously associated with ALS (Chia et al., 2018).