SOD1 and amyotrophic lateral sclerosis: This gene seems in fact to be involved in ALS pathogenesis, as enhanced secretion of TGF-beta1 was observed in reactive astrocyte that greatly contributed to motor neuron protein aggregation and neurite degeneration, e.g., via the inhibition of cellular autophagy, independently from SOD1 wild-type/mutation status (Tripathi et al., 2017).