NFASC and amyotrophic lateral sclerosis: Significant increase of NF was found in the CSF and serum of ALS patients, thus justifying its inclusion in the diagnostic protocol as well as in the evaluation of clinical course, given an increased level of NF-light chain in CSF of ALS that was found to be predictive of rapid clinical progression (Tortelli et al., 2015; Steinacker et al., 2016).