In this study, we performed targeted sequencing in a discovery cohort containing approximately 1,000 AAs to identify new potentially causal variants in risk genes previously implicated in AD risk in AAs (ABCA7, AKAP9, COBL, MS4A6A, PTK2B, SLC10A2, and ZCWPW1) or in AD and related traits in other populations. Here, PTK2B is linked to Alzheimer disease.