ABCA7 and Alzheimer disease: Cukier et al. (2016) identified a 44 base pair (bp) frameshift deletion in ABCA7 (rs142076058) that is in linkage disequilibrium (LD) with rs115550680 and thus may be the functional variant underlying the observed association. A recent exome sequencing investigation in an AA cohort of 198 AD cases and 304 controls examined 20 putative AD risk genes implicated by GWAS in EAs, and found nominally (uncorrected) significant associations with two ABCA7 variants (rs3764647 and rs3752239) and with gene-based tests of coding variants in MS4A6A, PTK2B, and ZCWPW1 (N’Songo et al., 2017).