Given the previously identified relationship between loss of function mutations in ABCA7 and AD (Cuyvers et al., 2015; Farrer, 2015; Steinberg et al., 2015; Cukier et al., 2016) and genetic and biological evidence for a role of rare AKAP9 variants in AD (Logue et al., 2014; Ikezu et al., 2018), the novel ABCA7 coding. Here, ABCA7 is linked to Alzheimer disease.