A GWAS of a brain MRI measure of hippocampal atrophy in a MIRAGE Study sample composed primarily of AD and control subjects of European ancestry and a smaller group of AAs (many of which are included in this study) found genome-wide significant association with several common SNPs spanning portions of F5 and its immediate neighbor, SELP, that was supported by evidence in both populations (Melville et al., 2012). This evidence concerns the gene SELP and Alzheimer disease.