WASHC5 and hippocampal atrophy: Finally, examination of the entire set of 104,341 variants identified in the targeted sequencing experiments yielded significant associations with multiple loci (Table 8), most notably a rare protective variant in F5 (rs2027885, OR for minor allele A = 0.053, p = 6.40 × 10-5), a gene that was previously associated with a MRI measure of hippocampal atrophy (Melville et al., 2012), and two common variants in KIAA0196 (p < 8.6 × 10-5; Table 8).