SELP and hippocampal atrophy: A GWAS of a brain MRI measure of hippocampal atrophy in a MIRAGE Study sample composed primarily of AD and control subjects of European ancestry and a smaller group of AAs (many of which are included in this study) found genome-wide significant association with several common SNPs spanning portions of F5 and its immediate neighbor, SELP, that was supported by evidence in both populations (Melville et al., 2012).