Abnormal activation of HH signaling results in constitutive activation of target genes that drive the oncogenesis of BCC, including SHH (600725), SMO (601500), GLI1 (165220), and GLI2 (165230) (Emmert, Schon, & Haenssle, 2014; Otsuka, Levesque, Dummer, & Kabashima, 2015; Wong & Dlugosz, 2014). The gene discussed is GLI1; the disease is skin basal cell carcinoma.