When compared between human MLL-rearrangement ( + ) (N = 18) and MLL-rearrangement (−) (N = 155) AML cases, mRNA levels of GNB2 extracted from RNA sequencing dataset were significantly upregulated in human MLL-rearrangement ( + ) cases (P = 0.031) (Fig. 5a). Here, GNB2 is linked to acute myeloid leukemia.