KMT2A and acute myeloid leukemia: As mentioned, wild-type GNB2 expression was elevated in human MLL-AML, which is consistent with the remarkable in vivo leukemogenesis due to overexpression of wild-type GNB2. To further confirm these findings, we reduced GNB2 expression by shRNA and depleted Gnb2 by CRISPR-Cas9 system.