In contrast, suppressing STAT3 activity or knocking down STAT3 reduced RhoA activity (Fig. 3k–m); in addition, overexpressing wild-type STAT3 increased phosphorylated MLC (Supplementary Fig. 3n), suggesting that STAT3 is located upstream of Rho-ROCK in DLBCL. This evidence concerns the gene RHOA and diffuse large B-cell lymphoma.