Also, cilia, which are normally present in control ductal cells30,31 but not in pancreatic intraepithelial neoplasia (PanIN) lesions and pancreatic cancer cells32, were found in pancreatic duct-like epithelial cells of Pdx1-Cre;HIF2dPA mice (Fig. 5E,F). This evidence concerns the gene PDX1 and pancreatic neoplasm.