DNMT1 and non-small cell lung carcinoma: We previously observed that β-elemene inhibited NSCLC cell growth via the extracellular signaling-regulated kinase 1/2 (ERK1/2)- and AMP-activated protein kinase α (AMPKα)-mediated inhibition of transcription factor Sp1 followed by a reduction in DNA methyltransferase 1 (DNMT1) expression7.