ACE and chronic kidney disease: Next a multiple linear regression analysis was performed using the change in eGFR as dependent variable and urine P/Cr as independent variable together with other variables that a priori were known to have the potential to accelerate the decline in eGFR: age, systolic blood pressure, low-density lipoprotein, uric acid, Alb/Cr ratio, ACE inhibitors-ARBs, glucose level, baseline CKD-EPI and ischemic heart disease.