CBX2 and amyotrophic lateral sclerosis: Furthermore, brains from Fus−/− mice or transgenic mice overexpressing ALS mutant FUS display up-regulation of Cbx2, Dot1l, Elf3, Prr12, and KMT2B (Scekic-Zahirovic et al., 2016; Shiihashi et al., 2016), and 17 of the 27 AT-hook genes are reported FUS RNA targets (Table S6).