FUS and frontotemporal dementia: Furthermore, TDP-43–positive inclusions are found in most sporadic ALS patients (Neumann et al., 2006; Taylor et al., 2016), and inclusions containing either TDP-43 or FUS are a pathological hallmark in ∼45% and ∼10% of patients with frontotemporal dementia (FTD), respectively (Ling et al., 2013).