These results raised two possibilities, either INC280 at high concentration (i.e., 30 mg/kg) can sufficiently block HGF-dependent MET activation in HGF-autocrine tumors at the same level as it does with METamp tumors, or, there are alternative targets other than the tumor cells that responded to INC280 in HGF-autocrine tumors. The gene discussed is HGF; the disease is neoplasm.