Increased HDAC4 nuclear shuttling was observed in the neurons of ischemic stroke model mice/ats and in oxygen-glucose deprivation (OGD)-treated neurons, while the overexpression of calcium/calmodulin-dependent protein kinase IV (CaMKIV) reduced the levels of nuclear HDAC4 in ischemic stroke [11, 64]. The gene discussed is CAMK4; the disease is ischemic stroke.