However, we observed a statistically significant difference in DNA methylation levels for A_prom CpG2 between AD cases and controls [21.7 ± 4.7% vs. 18.3 ± 4.8%; p value < 0.05], pointing to a differentially methylated region located within the alternative promoter of PLD3 in the AD hippocampus (Fig. 2b). The gene discussed is PLD3; the disease is Alzheimer disease.