We found that the average area of β-amyloid burden in the hippocampus was inversely correlated with PLD3 mRNA levels [tau-b = − 0,331; p value < 0.01], and accordingly, an inverse association was found between APS and PLD3 mRNA levels [tau-b = − 0,319; p value < 0.01]. Here, PLD3 is linked to autoimmune polyendocrinopathy.