LEP and diabetes mellitus: At the metabolic level, BSCL patients present dyslipidemia, hyperinsulinemia, disrupted carbohydrate metabolism, insulin resistance, diabetes mellitus (DM), hepatosplenomegaly, hepatic steatosis, acanthosis nigricans, low levels of leptin and adiponectin, decreased levels of high-density lipoprotein (HDL), and hypertriglyceridemia [2, 3].