CXCL8 and chronic obstructive pulmonary disease: Further, while we cannot disentangle whether arachidonic acid and IL-8 cause alterations in the lung virome or if virome changes cause increases in arachidonic acid and IL-8, these findings suggest that monitoring the lung virome of smokers may be important for assessing the “tipping point” in transitioning from a healthy lung environment to COPD.