Analysis of Copy Number Alteration (CNA), evaluated using the WES data on the whole primary tumor and metastases, showed a clear Her-2 amplification, shared by primary tumor and both metastasis (Additional file 1: Table S2) and an additional gain of the chromosomal region 6q21–22.33 (18 Mb), that in the second chest metastasis generated a focal amplification (39 copies) spanning RNF146 and ECHDC1 genes (Additional file 2: Figure S1A-C, Additional file 1: Table S2). The gene discussed is ERBB2; the disease is neoplasm.