MAPK8 and aortic aneurysm: In this regard, it has been reported that inhibitionof JNK markedly affects the initiation and progression of CVD.27,28 Previously, wehave identified JNK as a target by which rosiglitazone and IAXO-102 inhibitedAngiotensin II/TLR4-induced inflammatory responses in the mouse aorta and reducedmarkedly aortic aneurysm formation.17,20 In this study FP7 efficientlyinhibited JNK phosphorylation and negatively regulated a large number ofTLR4-dependent pro-inflammatory proteins in the mouse aorta.