Recently, it has been reported that the MD-2-directed synthetic TLR4 antagonist FP7inhibited TLR4 function and glycolytic re-programming of dendritic cells, andprotected mice from death due to TLR4-dependent influenza infection.23 In this study we showed that FP7 had the potential to inhibit haematopoieticand non-haematopoietic TLR4 signalling in response to distinct TLR4 ligands whichare associated with the pathogenesis of CVD. This evidence concerns the gene LY96 and influenza.