ERBB2 and breast cancer: MCF10A/p53−/PTEN− cells displayed that the activation of the Stat3/NF-kB pathway induces inflammatory cytokine production, in particular, that of IL6 and transforming growth factor beta (TGF-β), which appeared significantly increased in knocked down cells compared with parental, while the expression of SOCS3 is decreased or undetectable, as well as reduced, in luminal and HER2-positive breast cancer cell lines, or other breast cancer cells that are related to the IL-6 feedback loop [57].