Nonetheless, Gökmen-Polar Y et al., through tissue microarray from 133 BC patients, revealed that HOTAIR had a role as a biomarker of lymphatic metastases in ER-negative patients (p = 0.018) vs. ER-positive patients (p = 0.018); these data were validated using TCGA data from BC subjects [68]. Here, ESR1 is linked to breast cancer.