During two-stage skin carcinogenesis, the loss of TC-PTP promoted TPA-induced skin carcinogenesis via the upregulation of STAT3 and AKT signaling, whereas the inhibition of STAT3 or AKT recovered the effects of TC-PTP as a tumor suppressor in TC-PTP deficient cell lines (Figure 2) [141]. This evidence concerns the gene PTPN2 and neoplasm.