Another recent study showed that phospholipase C β3 (PLC-β3) recruits SHP1 and STAT5 to its C-terminal domain to facilitate the dephosphorylation of STAT5, which inhibits cell proliferation, survival, and differentiation, leading to the suppression of myeloproliferative disease, lymphoma, and other tumors in PLC-β3 knockout mice [84]. Here, PLCB3 is linked to myeloproliferative disorder.