Bta-miR-374a potentially targeted 36 different genes (Table S6b) and some of them might be important for ileum functions such as EIF2AK4, FBXO18, GTPBP3 and GNB2, etc. EIF2AK4 is an important transcription factor in host response to infection with pathogenic bacteria associated with Crohn’s disease [37]. The gene discussed is EIF2AK4; the disease is infection.