In humans, several miRNAs have been reported to participate in the regulation of intestinal transcription factors; miR-196b inhibited the GATA6 intestinal transcription factor to control intestinal cell homeostasis and tumorigenesis in colon cancer patients [55], while miR-30 family controlled intestinal epithelial cell proliferation and differentiation by targeting SOX9 (transcription factor) and other genes in ubiquitin ligase pathway [56]. Here, SOX9 is linked to colonic neoplasm.