LGALS3BP and Hepatic fibrosis: The two representatives of direct markers, Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP) and enhanced liver fibrosis (ELF) score, are different from Fib-4 index and APRI in that WFA-M2BP and ELF score directly measure components of the extracellular matrix produced by activated stellate cells in fibrotic liver [17,18].